Notre département de Biologie moléculaire offre plusieurs analyses du génétique médicale. Ces analyses concernent:
Identification des anomalies génétiques:
| HLA B27 Génotypage |
| Facteur II Prothrombine |
| Facteur V de leiden |
| Lactose Intolérance |
| HLA B51 de Classe I |
| HLA de Class I et II dans le cadre d’une greffe |
Identification des micro-organismes pathogènes:
| PANEL BACTERIAL | Mycobacterium tuberculosis complex Streptococcus pneumoniae Streptococcus agalactiae Haemophilus influenzae Listeria monocytogenes | Treponema pallidum Neisseria meningitidis Coxiella burnetii Borrelia burgdorferi Cryptococcus neoformans (fungus) |
| PANEL VIRAL | Herpes Simplex Virus -1 Herpes Simplex Virus -2 Cytomegalovirus Epstein Barr Virus | Varicella-Zoster Toscana Virus Enterovirus Parechovirus |
| PANEL SEPSIS | Streptococcus pneumoniae Stenotrophomonas maltophilia Candida spp. Acinetobacter baumannii Serratia marcescens/ Klebsiella pneumonia Streptococcus agalactiae Staphylococcus spp. Staphylococcus aureus Escherichia coli Enterobacter spp. Candida albicans Listeria monocytogenes Enterococcus spp. Pseudomonas aeruginosa Klebsiella pneumoniae Streptococcus spp. | Neisseria meningitidis Proteus spp. Methicillin resistance gene Vancomycin resistance gene Vancomycin resistance gene Class A carbapenemase ß-lactamase SHV Extended-spectrum ß-lactamase CTX-M Class A carbapenemase Class B carbapenemase Class B carbapenemase IMP3, 15, 19_like Class D carbapenemase OXA23_like Class D carbapenemase OXA24_like Class D carbapenemase OXA48_like Class D carbapenemase OXA51_like Class D carbapenemase OXA58_like |
| HPV PANEL | 36 different Type de HPV | |
| Panel Respiratoire | Influenza virus A Influenza virus A H1N1 Influenza virus AH3 Influenza virus B Human metapneumovirus Respiratory syncytial virus A Respiratory syncytial virus B Enterovirus Rhinovirus Human parainfluenza virus type 1 | Human parainfluenza virus type 2 Human parainfluenza virus type 3 Human parainfluenza virus type 4 Adenovirus Bocavirus Human Coronavirus 229E Human Coronavirus HKU-1 Human Coronavirus NL63 Human Coronavirus OC43 SARS-COV-2 Bordetella pertussis |
Génétique moléculaire des cancers:
| ONCOMINE BRCA1/2 PANEL | FULL GENE: BRCA1, BRCA2. |
| ONCOMINE BRCA EXPANDED PANEL | FULL GENE: ATM, FANCD2, RAD54L, BARD1, MRE11, CHEK2, BRCA1, NBN, CDK12, BRCA2, PALB2, RAD51B, BRIP1, PPP2R2A, TP53. |
| HOTSPOT PANEL | HOTSPOT: ABL1, EGFR, GNAS, KRAS, PTPN11, AKT1, ERBB2, GNAQ, MET, RB1, ALK, ERBB4, HNF1A, MLH1, RET, APC, EZH2, HRAS, MPL , SMAD4, ATM, FBXW7, IDH1, NOTCH1, SMARCB1, BRAF, FGFR1, JAK2, NPM1, SMO, CDH1, FGFR2, JAK3, NRAS, SRC, CDKN2A, FGFR3, IDH2, PDGFRA, STK11, CSF1R, FLT3, KDR, PIK3CA, TP53, CTNNB1, GNA11, KIT, PTEN, VHL. |
| ONCOMINE FOCUS PANEL | HOTSPOT: AKT1, IDH2, CTNNB1, DDR2, EGFR, ERBB2, ERBB3, ERBB4, ESR1, FGFR2, FGFR3, GNA11, GNAQ, HRAS, IDH1, JAK1, JAK2, JAK3, KIT, KRAS, MAP2K1, MET, MTOR, MAP2K2, NRAS, SMO ,PDGFRA, RAF1, RET, PIK3CA, ROS1, ALK, AR, BRAF, CDK4. COPY NUMBER VARIATION: AKT1, ALK, AR, BRAF, CCND1, CDK4, CDK6, EGFR, ERBB2, FGFR1, FGFR2, FGFR3, FGFR4, KIT, KRAS, MET, MYCN, PDGFRA, PIK3CA, MYC. GENE FUSIONS: BL1, AKT3, ALK, AXL, BRAF, EGFR, ERBB2, ERG, ETV1, ETV4, ETV5, FGFR1, FGFR2, FGFR3, MET, NTRK1, NTRK2, NTRK3, RAF1, PDGFRA, RET, PPARG, ROS1. |
| ION AMPLISEQ COLORECTAL AND LUNG CANCER PANEL | HOTSPOT: 2 KRAS, NRAS, FGFR2, EGFR, STK11, FGFR1, BRAF, MAP2K1, ERBB4, PIK3CA, ALK, FBX7, AKT1, DDR2, NOTCH1, ERBB2, CTNNB1, SMAD4, PTEN, MET, FGFR3, TP53. |
| ONCOMINE MYELOID PANEL | HOTSPOT: ABL1, BRAF, CBL, CSF3R, DNMT3A, FLT3, GATA2, HRAS, IDH1, IDH2, JAK2, KIT, KRAS, MPL ,MYD88, NPM1, NRAS, PTPN11, SETBP1, SF3B1, SRSF2, U2AF1, WT1. FULL GENE: ASXL1, BCOR, CALR, CEBPA, ETV6, EZH2, IKZF1, NF1, PHF6, PRPF8, RB1, RUNX1, SH2B3, STAG2, TET2, TP53, ZRSR2. GENE FUSIONS: ABL1, ALK, BCL2, BRAF, CCND1, CREBBP, EGFR, ETV6, FGFR1, FGFR2, FUS, HMGA2 ,JAK2, KMT2A, MECOM, MET, MLLT10, MLLT3, MYBL1, MYH11, NTRK3, NUP214, PDGFRA, PDGFRB, RARA, RBM15, RUNX1, TCF3, TFE3. EXPRESSION GENES: BAALC, MECOM, MYC, SMC1A, WT1. |